Home 23 European Symposium on Computer Aided Process Engineering: Mixed integer optimisation of antibody purification processes (Computer Aided Chemical Engineering Book 32)

23 European Symposium on Computer Aided Process Engineering: Mixed integer optimisation of antibody purification processes (Computer Aided Chemical Engineering Book 32)

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File Size: 584 KB
Print Length: 22 pages
Publisher: Elsevier (June 10, 2013)
Publication Date: June 10, 2013
Sold by: Amazon Digital Services LLC
Language: English
ASIN: B019ZUEAL0
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Word Wise: Enabled
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Format: PDF ePub djvu book

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Chromatographic operations are identified as critical steps in a monoclonal antibody (mAb) purification process and can represent a significant proportion of the purification material costs. The optimisation of chromatography equipment sizing strategies is therefore crucial to improve the cost-effectiveness of mAb manufacture. In this work, a mixed-integer linear programming model (MILP) was developed to determine the optimal chromatography colum...

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